Medications and Magnesium: What You Need to Know

By Bec McInnes

Ever wondered why you still feel tired, wired, twitchy, tense, or completely over it, even when you’re trying to do all the “right” things?

The answer might be hiding in your medicine cabinet.

Some medications can affect how your body absorbs, uses, or holds onto magnesium. And because magnesium supports normal muscle function, nervous system function, energy production, and relaxation, low levels can leave you feeling a bit flat, tight, stressed, and not quite yourself.

Rude, honestly.

This does not mean you should stop or change your medication. Absolutely not. But it does mean magnesium is worth understanding, especially if you are on long-term medication and feeling more depleted than usual.

The Medication and Magnesium Connection

Think of magnesium like money in a bank account. You need regular deposits, but certain medications can create extra withdrawals, make deposits harder, or change how your body uses what is already there.

Over time, that can matter.

And because busy women are already running on decision fatigue, interrupted sleep, caffeine, snack scraps, and pure stubbornness, anything that chips away at your reserves deserves a little attention.

Medications That May Affect Magnesium

Some medications are known to interact with magnesium levels or magnesium supplements. These can include:

  • Proton pump inhibitors, often used for reflux and heartburn
  • Some diuretics, also known as fluid tablets
  • Some antibiotics, which may bind with magnesium supplements
  • Some medications for bone health, which may need to be taken away from magnesium

This is not a complete list, and it does not mean these medications are “bad”. It simply means it is worth checking in with your doctor, pharmacist, or qualified health professional if you are taking regular medication and considering magnesium supplements.

Why This Matters

Magnesium is involved in hundreds of processes in the body. It helps support:

  • Normal muscle function
  • Nervous system function
  • Energy production
  • Relaxation and wind-down
  • Healthy sleep patterns

So if your magnesium intake is low, or your body is losing more than usual, you may notice things like:

  • Tiredness that does not quite shift
  • Tight muscles or cramps
  • Restless legs
  • Feeling wired but exhausted
  • Trouble switching off at night
  • More tension in your neck, shoulders, jaw, or legs

Classic body-doing-the-most behaviour.

Three Ways Medication Can Affect Magnesium

1. Your body may lose more magnesium

Some medications, such as certain diuretics, can increase how much magnesium leaves the body through urine.

It is a bit like trying to fill a bath while the plug is slightly open. Annoying. Not ideal. Very on brand for modern life.

2. Your body may absorb less magnesium

Long-term use of some acid-reducing medications may affect magnesium levels in some people. If you have been taking reflux medication for a while and feel unusually tired, crampy, or weak, it is worth speaking with your healthcare provider.

3. Magnesium may affect how some medications are absorbed

This is especially important with some antibiotics and bone health medications. Magnesium can bind with certain medicines, which may reduce how well they are absorbed.

Translation: timing matters.

Your doctor or pharmacist can tell you how far apart to take magnesium and your medication if needed.

How To Support Magnesium Safely

If you are on medication, the first step is always to check with your doctor, pharmacist, or qualified health professional before adding supplements.

Once you have the all-clear, there are a few simple ways to support your magnesium intake.

1. Magnesium-rich foods

Add more magnesium-rich foods where you can, without turning your life into a full-time meal-prep spreadsheet.

  • Leafy greens
  • Nuts and seeds
  • Legumes
  • Whole grains
  • Dark chocolate, thank you very much

2. Topical magnesium

Topical magnesium can be a simple option for tired, tight bodies. You apply it directly to the skin where your body needs support.

No tablets. No complicated steps. No wellness theatre.

3. Small daily support

You do not need to become a brand-new person with a 17-step wellness plan.

Start simple:

  • Spray tired legs after your shower
  • Massage cream into tight shoulders before bed
  • Add a magnesium soak to the bath after a huge day
  • Ask your pharmacist about timing if you take medication

The Salt + Earth Approach

Our magnesium products are made for real life. Busy bodies. Tired mums. Long days. Tight shoulders. Nervous systems doing the absolute most.

They are not designed to replace medication or medical advice. They are simple topical magnesium support for bodies that feel tense, tired, and a little bit over it.

Shop Magnesium Support

Simple topical magnesium support for tight muscles, tired bodies, and end-of-day tension.

The Bottom Line

If you are on long-term medication and feeling unusually tired, tense, crampy, wired, or depleted, magnesium may be worth discussing with your healthcare provider.

Do not stop or change medication on your own. Do not guess your way through interactions. Get proper advice.

But do listen to your body.

Because sometimes feeling better starts with understanding what your body is asking for.

Salty love,
Dr. Bec


Dr. Bec, founder of Salt + Earth Co.

By Dr. Bec

Dr. Bec is an Osteopath, Naturopath, mum of two, and founder of Salt + Earth Co. She writes about tired bodies, busy brains, nervous systems doing the most, and simple support that fits into real life. No wellness theatre. No miracle claims. Just practical help for women who are holding a lot.

Please note: This blog is for educational purposes only and is not a replacement for medical advice from a registered doctor, pharmacist, or qualified health professional. Always speak with your healthcare provider before adding magnesium if you take medication, are pregnant, breastfeeding, have kidney disease, or have ongoing symptoms or health concerns.

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